You can configure a TCP connection to a DB system during target database registration.

To establish a TCP connection between the target database and Oracle Data Safe during target database registration, the database must have both the network encryption and data integrity features enabled. By default, when a DB system is created, the required network encryption is enabled.

The supported encryption algorithm is AES256. Supported cryptographic hash functions for checksum are SHA1, SHA256, SHA384, and SHA512. Non-encrypted TCP connections are not supported.