Oracle Data Safe supports TCP and TLS connections to target databases.
During target database registration, you configure a connection between Oracle Data Safe and a target database. Oracle Data Safe is considered a client of a target database. The connection type can be Transmission Control Protocol (TCP) or Transport Layer Security (TLS). A TLS connection is a TCPS connection that uses TLS cryptographic protocol. Oracle Data Safe supports version 1.2 of the TLS protocol, but not the Secure Sockets Layer (SSL) cryptographic protocol. Using a TLS connection to a target database provides privacy and data integrity, plus the identity of the communicating parties can be authenticated by using public key cryptography. Although authentication can be optional, the server typically requires it.
You can register an Autonomous Database from the database's console in Oracle Cloud Infrastructure. Autonomous Databases have TLS encryption enabled with client authentication. During registration, Oracle Cloud Infrastructure automatically creates a TLS connection between the Autonomous Database and Oracle Data Safe and takes care of the registration details for you.
You can register a DB system from the Oracle Data Safe Console. During registration, you specify registration details and configure a TCP or TLS connection. If your DB system has TLS configured, then you should choose TLS over TCP.